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Mannitol E421-CAS-No.585-55-6
Mannitol E421-CAS-No.585-55-6 has six alcohol is due to endothermic dissolution, sweet, have oral discomfort, it is more widely used in medicine to sober up, mouth refreshing agent chewable tablets manufacturing. E421 used for the food industry, chemical industry, pharmaceutical industry.
Mannitol E421-CAS-No.585-55-6 for maltose in the food, chewing gum, cakes, bodybuilding foods.
Mannitol E421-CAS-No.585-55-6 in the industry for the plastics industry, the system rosin esters, synthetic glycerol resins, explosives, detonators, etc.


  • E No:E421
  • CAS No:585-55-6
  • Einecs No:200-711-8
  • HS Code:29054300
  • Specification:BP/USP/EP/CP/FCC IV
  • Routine Packing:25kg
  • Place of origin:China
  • QC:ISO
  • Payment terms:T/T or L/C
  • Port of dispapch:anghai,Qindao
  • Function:type7
  • Applications:type14


    • Item
    • Specification-- BP/USP/EP/CP/FCC IV
    • Name
    • Mannitol; Manitol; Mannite
    • Appearance
    • white crystalline powder
    • Acidity
    • ≤0.30ml
    • Identification
    • conformed to the standard
    • Assay
    • 98.0-102.0%
    • Molecular Formula
    • C6H14O6
    • Melting point
    • 166-170℃
    • Solution clarification
    • conform
    • Specific Optical Rotation
    • +23o~+25o
    • TLC
    • Conformity
    • Conductivity
    • ≤20us/cm
    • Reducing Sugars
    • ≥12.8ml
    • Related Substances:
      The area of any peak Total Impurities

    • ≤2%
    • Chloride
    • ≤0.003%
    • Sulphate
    • ≤0.01%
    • Oxalate
    • ≤0.02%
    • Loss on drying
    • ≤0.5%
    • Residue on ignition
    • ≤0.1%
    • Heavy metals
    • ≤10ppm
    • As
    • ≤2ppm
    • Microbiology
    • Bacterial Endotoxins
    • ≤2.5IU/g
    • Microbial Contamination:
      Escherichia Coli

    • ≤100cfu/g


Mannitol E421-CAS-No.585-55-6 nature:
White needle crystal. Melting point 166, the relative density of 1.52,1.489 (20 ℃), boiling point 290-295 ℃ (467kPa). 1g Mannitol E421 can be dissolved in about 5.5ml of water (about 18%, 25 ℃), 83ml alcohol, more soluble in water, soluble in pyridine and aniline, insoluble in ether. Aqueous solution is alkaline. E421 is sorbitol isomerization body, sorbitol hygroscopicity strong, and the product no moisture absorption. E421 sweet, its sweetness equivalent to sucrose 70%.

Mannitol E421-585-55-6 uses:

The pleasant taste and mouthfeel of E421 also makes E421 a popular excipient for chewable tablets.
Mannitol E421-585-55-6 in medicine is a good diuretic to reduce intracranial pressure, intraocular pressure and renal drugs, dehydration, sugar substitutes, also used as tablet excipients and solid, liquid diluent. E421 injection as the high penetration of antihypertensive drugs, the clinical brain disorders, especially rescue the rescue of a drug commonly used, E421 to reduce intracranial pressure with antihypertensive drugs require rapid, effective and accurate. Mannitol E421 used as a tablet excipients, Mannitol E421 no moisture absorption, fast drying, good chemical stability, but also has tasty, and good grain characteristics, Mannitol E421 for anti-cancer drugs, antibiotics, antihistamines and vitamins, and most other tablets. In addition, Mannitol E421 is also used to sober up drugs, mouth refreshing agent Chewable agent. In the food sector, Mannitol E421 in sugar and sugar alcohols in the minimum water absorption, and sweet with a refreshing, for maltose, chewing gum, cakes and other foods of anti-sticking, and as a general anti-sticking pastry flour. E421 can also be used in patients with diabetes, food, fitness and food low calorific value, low-sugar sweetener.
In industry, E421-CAS-No.585-55-6 can be used for the plastics industry, manufacturing rosin ester resins and synthetic glycerin, explosives, detonators (nitrification mannitol) and so on. In the chemical analysis for the determination of boron in biological testing for bacterial culture on the agent. E421, although that can be absorbed by the gastrointestinal, but does not accumulate in the body. E421 is absorbed, is metabolized in the body part, other part in the urine; by hydrobromic acid can be obtained dibromo mannitol.
Currently, the worlds industrial production E421 has two main kinds of processes, one based on kelp as raw materials in the production of alginate at the same time, will be submitted after kelp iodine soaking, after repeated Concentration, impurity, from the cross, evaporation, cooling crystallization derived from E421; One is based on sucrose and glucose as raw material by hydrolysis, epimerization and isomerization enzyme, and then hydrogenation E421.


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